Part I: Genomics
The Complete Blueprint
Genomics is the comprehensive study of an organism's entire genetic material — its genome. From the hierarchical organization of DNA into chromosomes to the revolutionary sequencing technologies that made the Human Genome Project possible, genomics provides the foundation for all other omics disciplines. This part covers genome architecture, sequencing methods from Sanger to nanopore, genome assembly algorithms, and functional and comparative genomics.
3.2 Gbp
Human Genome Size
~20,000
Protein-Coding Genes
$100
Genome Sequencing Cost
Topics in This Part
1. Genome Organization & Architecture
Chromosome structure, chromatin packaging, repetitive elements, gene density, and genome size variation across species
2. DNA Sequencing Technologies
Sanger sequencing, next-generation platforms (Illumina, Ion Torrent), and third-generation long-read technologies (PacBio, Oxford Nanopore)
3. Genome Assembly & Annotation
de Bruijn graphs, overlap-layout-consensus, scaffolding, gene prediction, and functional annotation pipelines
4. Comparative & Functional Genomics
Synteny analysis, ortholog/paralog identification, GWAS, CRISPR screens, and evolutionary genomics