Replication Repair

Biochemistry · Part 3

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Table of Contents

  1. 1.Semiconservative Replication
  2. 2.The Replication Machinery
  3. 3.Proofreading and Fidelity
  4. 4.Eukaryotic Replication
  5. 5.DNA Damage
  6. 6.DNA Repair Mechanisms
  7. 7.Genetic Recombination
  8. 8.Leading Strand
  9. 9.Lagging Strand
  10. 10.Key Concepts

Key Equations

$$\text{dNTP} + \text{DNA}_n \xrightarrow{\text{DNA Pol}} \text{DNA}_{n+1} + \text{PP}_i \quad (\Delta G^{\circ\prime} \approx -3.4 \text{ kJ/mol per step; driven by PP}_i \text{ hydrolysis})$$
$$\text{Base selection by polymerase: } \sim 10^{-5} \text{ errors per bp}$$
$$\text{3}'\text{→5}' \text{ exonuclease proofreading: } \sim 10^{-7} \text{ errors per bp}$$
$$\text{Post-replication mismatch repair: } \sim 10^{-9} \text{ to } 10^{-10} \text{ errors per bp}$$

Equations are rendered with MathJax in the PDF with professional LaTeX typesetting.

Course Context

This PDF is part of the Biochemistry course on CoursesHub.World. Study biochemistry with 100 free video lectures covering amino acids, protein structure, enzyme kinetics, carbohydrates, lipids, and metabolism including glycolysis, the TCA cycle, and oxidative phosp...

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