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Biochemistry · Part 3

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Table of Contents

  1. 1.The Central Dogma
  2. 2.Prokaryotic Transcription
  3. 3.Eukaryotic Transcription
  4. 4.Post-Transcriptional Processing
  5. 5.The Genetic Code
  6. 6.Translation: Protein Synthesis
  7. 7.Post-Translational Modifications & Protein Targeting
  8. 8.Key Concepts Summary
  9. 9.Exceptions to the Central Dogma
  10. 10.RNA Polymerase Subunit Composition

Key Equations

$$\text{NTP} \rightarrow \text{NMP}_{\text{(RNA)}} + \text{PP}_i, \quad \Delta G^{\circ'} \approx -33.5 \text{ kJ/mol (with PP}_i \text{ hydrolysis)}$$
$$4^3 = 64 \text{ codons for 20 amino acids + stop signals}$$
$$\text{Amino acid} + \text{tRNA} + \text{ATP} \rightarrow \text{Aminoacyl-tRNA} + \text{AMP} + \text{PP}_i$$
$$\underbrace{2 \text{ ATP}}_{\text{aminoacyl-tRNA charging}} + \underbrace{1 \text{ GTP}}_{\text{EF-Tu delivery}} + \underbrace{1 \text{ GTP}}_{\text{EF-G translocation}} = 4 \text{ high-energy phosphate bonds per residue}$$

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Course Context

This PDF is part of the Biochemistry course on CoursesHub.World. Study biochemistry with 100 free video lectures covering amino acids, protein structure, enzyme kinetics, carbohydrates, lipids, and metabolism including glycolysis, the TCA cycle, and oxidative phosp...

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