Lipid Metabolism

Biochemistry · Part 5

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Table of Contents

  1. 1.Overview of Lipid Metabolism
  2. 2.The Carnitine Shuttle
  3. 3.-Oxidation
  4. 4.ATP Yield from Fatty Acid Oxidation
  5. 5.Unsaturated and Odd-Chain Fatty Acid Oxidation
  6. 6.Ketogenesis
  7. 7.Fatty Acid Synthesis (Lipogenesis)
  8. 8.Cholesterol Synthesis
  9. 9.Python: -Oxidation ATP Yield Calculator
  10. 10.Key Concepts

Key Equations

$$\text{Fatty acid} + \text{CoA} + \text{ATP} \rightarrow \text{Acyl-CoA} + \text{AMP} + \text{PP}_i \quad (\text{costs 2 ATP equivalents})$$
$$\text{Total ATP} = 8(10) + 7(2.5) + 7(1.5) - 2 = 80 + 17.5 + 10.5 - 2 = \boxed{106 \text{ ATP}}$$
$$\text{Propionyl-CoA} \xrightarrow[\text{biotin}]{\text{propionyl-CoA carboxylase}} \text{D-Methylmalonyl-CoA} \xrightarrow{\text{racemase}} \text{L-Methylmalonyl-CoA} \xrightarrow[\text{vitamin B}_{12}]{\text{mutase}} \text{Succinyl-CoA}$$
$$\text{Acetyl-CoA} + \text{CO}_2 + \text{ATP} \xrightarrow[\text{biotin}]{\text{ACC}} \text{Malonyl-CoA} + \text{ADP} + \text{P}_i$$

Equations are rendered with MathJax in the PDF with professional LaTeX typesetting.

Course Context

This PDF is part of the Biochemistry course on CoursesHub.World. Study biochemistry with 100 free video lectures covering amino acids, protein structure, enzyme kinetics, carbohydrates, lipids, and metabolism including glycolysis, the TCA cycle, and oxidative phosp...

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