Tca Cycle

Biochemistry · Part 5

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Table of Contents

  1. 1.Overview of the TCA Cycle
  2. 2.Pyruvate Dehydrogenase Complex
  3. 3.The Eight Reactions of the TCA Cycle
  4. 4.Regulation of the TCA Cycle
  5. 5.Anaplerotic Reactions
  6. 6.Amphibolic Nature of the TCA Cycle
  7. 7.Python: TCA Cycle Energetics
  8. 8.Key Concepts
  9. 9.Why “Cycle”?
  10. 10.Step 1: Citrate Synthase

Key Equations

$$\text{Acetyl-CoA} + 3\,\text{NAD}^+ + \text{FAD} + \text{GDP} + \text{P}_i + 2\,\text{H}_2\text{O} \;\longrightarrow\; \text{CoA-SH} + 3\,\text{NADH} + \text{FADH}_2 + \text{GTP} + 2\,\text{CO}_2$$
$$\text{Acetyl-CoA} + \text{OAA} + \text{H}_2\text{O} \rightarrow \text{Citrate} + \text{CoA-SH} \qquad \Delta G^{\circ\prime} = -31.4\;\text{kJ/mol}$$
$$\text{Isocitrate} + \text{NAD}^+ \rightarrow \alpha\text{-Ketoglutarate} + \text{CO}_2 + \text{NADH} \qquad \Delta G^{\circ\prime} = -20.9\;\text{kJ/mol}$$
$$\text{Succinyl-CoA} + \text{GDP} + \text{P}_i \rightarrow \text{Succinate} + \text{CoA-SH} + \text{GTP} \qquad \Delta G^{\circ\prime} = -2.9\;\text{kJ/mol}$$

Equations are rendered with MathJax in the PDF with professional LaTeX typesetting.

Course Context

This PDF is part of the Biochemistry course on CoursesHub.World. Study biochemistry with 100 free video lectures covering amino acids, protein structure, enzyme kinetics, carbohydrates, lipids, and metabolism including glycolysis, the TCA cycle, and oxidative phosp...

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