Pharmacology

A comprehensive graduate-level course on pharmacology—from drug-receptor theory and pharmacokinetics through systems pharmacology, therapeutic areas, drug development, and pharmacogenomics.

Course Overview

Pharmacology is the science of how drugs interact with biological systems to produce therapeutic effects. This course covers the complete pipeline from molecular drug-receptor interactions and dose-response relationships through clinical pharmacology, drug development, and the emerging field of pharmacogenomics.

What You'll Learn

  • • Drug-receptor theory and binding kinetics
  • • Pharmacokinetics: ADME and compartment models
  • • Pharmacodynamics and dose-response relationships
  • • Autonomic and cardiovascular pharmacology
  • • CNS pharmacology and antimicrobials
  • • Anti-inflammatory, endocrine, and chemotherapy agents
  • • Drug development and clinical trials
  • • Pharmacogenomics and toxicology

Prerequisites

References

  • • H. P. Rang et al., Rang & Dale's Pharmacology (9th ed.)
  • • L. L. Brunton et al., Goodman & Gilman's The Pharmacological Basis of Therapeutics
  • • B. G. Katzung, Basic & Clinical Pharmacology
  • • S. M. Stahl, Stahl's Essential Psychopharmacology

Ninja Nerd Pharmacology Library

Undergraduate-level companion videos from the Ninja Nerd Pharmacology series — antimicrobial, autonomic, cardiovascular, and CNS drug classes plus pharmacokinetic/pharmacodynamic foundations. Use as a clinical refresher before working through the quantitative parts of the course.

Pharmacokinetics & Pharmacodynamics

Ninja Nerd · Pharmacology

Drug Absorption

Ninja Nerd · Pharmacology

Drug Metabolism

Ninja Nerd · Pharmacology

Drug Distribution

Ninja Nerd · Pharmacology

Drug Excretion

Ninja Nerd · Pharmacology

Drug Clearance

Ninja Nerd · Pharmacology

Dosage Regimen

Ninja Nerd · Pharmacology

Pharmacodynamics

Antimicrobials

Ninja Nerd · Pharmacology

Antibiotics

Ninja Nerd · Pharmacology

Antivirals: HIV, Hepatitis, Influenza, Herpes

Ninja Nerd · Pharmacology

Antifungals

Ninja Nerd · Pharmacology

Antimycobacterials — Anti-TB Drugs

Autonomic Pharmacology

Ninja Nerd · Pharmacology

Cholinergic Agonists

Ninja Nerd · Pharmacology

Muscarinic Antagonists

Ninja Nerd · Pharmacology

Adrenergic Agonists

Ninja Nerd · Pharmacology

Adrenergic Antagonists

Cardiovascular Pharmacology

Ninja Nerd · Pharmacology

Antihypertensive Drugs

Ninja Nerd · Pharmacology

Antianginal Drugs

Ninja Nerd · Pharmacology

Antiarrhythmic Drugs

Ninja Nerd · Pharmacology

Antiplatelet, Anticoagulant & Thrombolytic Agents

Ninja Nerd · Pharmacology

Diuretics

CNS & Neurological Pharmacology

Ninja Nerd · Pharmacology

Anxiolytic & Hypnotic Drugs

Ninja Nerd · Pharmacology

Parkinson’s Disease Drugs

Ninja Nerd · Pharmacology

Migraine Medications

Course Structure

Key Equations

Hill Equation

$$E = \frac{E_{\max} [A]^n}{EC_{50}^n + [A]^n}$$

Sigmoidal dose-response with Hill coefficient n

Michaelis-Menten Kinetics

$$v = \frac{V_{\max} [S]}{K_m + [S]}$$

Enzyme kinetics: rate as a function of substrate concentration

Schild Plot

$$\log(DR - 1) = \log[B] - \log K_B$$

Determines antagonist affinity from dose ratios

One-Compartment Model

$$C(t) = C_0 \, e^{-k_e t}, \quad t_{1/2} = \frac{\ln 2}{k_e}$$

First-order elimination pharmacokinetics

Henderson-Hasselbalch

$$\text{pH} = \text{p}K_a + \log \frac{[A^-]}{[HA]}$$

Determines ionization state affecting drug absorption

Emax Model

$$E = \frac{E_{\max} \cdot C}{EC_{50} + C}$$

Hyperbolic concentration-effect relationship

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