Genome Assembly

Genomics, Proteomics, Transcriptomics & Metabolomics · Part 1

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Table of Contents

  1. 1.Assembly Strategies: De Novo vs. Reference-Guided
  2. 2.Assembly Algorithms: OLC & De Bruijn Graphs
  3. 3.Assembly Quality Metrics
  4. 4.Gene Prediction & Structural Annotation
  5. 5.Sequence Similarity Search & Functional Annotation
  6. 6.De Novo Assembly
  7. 7.Reference-Guided Assembly
  8. 8.Overlap-Layout-Consensus (OLC)
  9. 9.De Bruijn Graph Approach
  10. 10.De Bruijn Graph Construction

Key Equations

$$C_k = C \times \frac{L - k + 1}{L}$$
$$\text{N50} = \text{length } L \text{ such that } \sum_{\substack{i \\ l_i \geq L}} l_i \geq \frac{1}{2} \sum_{i} l_i$$
$$\text{GC Content} = \frac{G + C}{A + T + G + C} \times 100\%$$
$$E = K \cdot m \cdot n \cdot e^{-\lambda S}$$

Equations are rendered with MathJax in the PDF with professional LaTeX typesetting.

Course Context

This PDF is part of the Genomics, Proteomics, Transcriptomics & Metabolomics course on CoursesHub.World. Study genomics, proteomics, transcriptomics and metabolomics with 20 free chapters covering DNA sequencing, RNA-Seq, mass spectrometry, metabolic profiling, multi-omics integration, and precision medi...

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