Genome Organization

Genomics, Proteomics, Transcriptomics & Metabolomics · Part 1

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Table of Contents

  1. 1.Genome Size & the C-Value Paradox
  2. 2.Chromatin Structure & Nucleosome Organization
  3. 3.Euchromatin, Heterochromatin & Chromosome Territories
  4. 4.Repetitive Elements & Non-Coding DNA
  5. 5.The Human Genome Project & Key Statistics
  6. 6.Centromeres, Telomeres & Chromosomal Architecture
  7. 7.Definition: C-Value
  8. 8.The Nucleosome Core Particle
  9. 9.Histone Octamer Assembly
  10. 10.Nucleosome Repeat Length

Key Equations

$$C = \frac{\text{Total haploid DNA (pg)}}{1} \quad \text{where } 1\,\text{pg} \approx 978\,\text{Mb}$$
$$\text{Octamer} = (\text{H3})_2(\text{H4})_2(\text{H2A})_2(\text{H2B})_2$$
$$\text{Packaging Ratio} = \frac{\text{Length of DNA}}{\text{Length of structure containing it}}$$
$$(\text{TTAGGG})_n + \text{dNTPs} \xrightarrow{\text{Telomerase}} (\text{TTAGGG})_{n+k}$$

Equations are rendered with MathJax in the PDF with professional LaTeX typesetting.

Course Context

This PDF is part of the Genomics, Proteomics, Transcriptomics & Metabolomics course on CoursesHub.World. Study genomics, proteomics, transcriptomics and metabolomics with 20 free chapters covering DNA sequencing, RNA-Seq, mass spectrometry, metabolic profiling, multi-omics integration, and precision medi...

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